J. Vernon Luck, Sr., M.D. Orthopaedic Research Center

the research team

Pat Campbell, PhD

 

Education

  • BS Honors in Anatomy & Human Biology, University of Western Australia 1980

  • PhD in Biomaterials and Handicap Research, Göteborg University, Sweden, 1995

Grants

Current and recent support includes grants and contracts from various orthopaedic implant manufacturers and private research foundations. 

Research Area

Dr. Campbell is the Director of the Implant Retrieval Laboratory of the JVL Orthopaedic Research Center, located at Orthopaedic Institute for Children (formerly Orthopaedic Hospital, founded in 1911) in Los Angeles. She has focused her research on the implant retrieval analysis of joint arthroplasties, with particular emphasis on the biological factors that affect the clinical performance of implants, histological scoring of periprosthetic tissues, and the evaluation of prosthetic joint fixation. More recently, she has conducted implant retrieval studies on retrieved megaprosthesis implants used for limb salvage operations frequently done in paediatric oncology patients. In addition, the clinical evaluation of lumbar and cervical disc replacements and the histology of tissue reactions associated with these devices have become a new area of study.  

Awards

  • The Hip Society John Charnley Award 1990

  • The Hip Society John Charnley Award 1994

  • American Academy of Orthopaedic Surgeons Kappa Delta Ann Doner Vaughn Award 1998

  • The Hip Society John Charnley Award 2006

  • The Hip Society Otto Aufranc Award 2012

Recent Publications

  1. Park, S. H., Lu, Z., Hastings, R. S., Campbell, P. A., & Ebramzadeh, E. (2018). Five hundred fifty-five retrieved metal-on-metal hip replacements of a single design show a wide range of wear, surface features, and histopathologic reactions. Clinical Orthopaedics and Related Research, 476(2), 261.

  2. Yuan, N., Park, S. H., Luck Jr, J. V., & Campbell, P. A. (2018). Revisiting the concept of inflammatory cell‐induced corrosion. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 106(3), 1148-1155.

  3. Campbell P, Park SH, Zoller S, Yousuf J, & Nelson SD. (2017). Solid corrosion products in the periprosthetic tissues of a distal femoral endoprosthesis used to treat osteosarcoma. Corrosion : Special Issue on Biocorrosion 73(12):1530-1537

  4. Campbell P, & Ebramzadeh E. ARMD and Presumed Dangerous!: Commentary on an article by Gulraj S. Matharu, et al.: “Blood Metal Ion Thresholds to Identify Patients with Metal-on-metal Hip Implants at Risk of Adverse Reactions to Metal Debris. An External Multicenter Validation Study of Birmingham Hip resurfacing and Corail-Pinnacle Implants”. 2017, Journal of Bone and Joint Surgery ;99(18)

  5. Kung MS, Campbell P, Markantonis J, Knutsen A, Ameri B, Park S-H, Ebramzadeh E: Histological characterization of chromium orthophosphate corrosion products from modular total hip replacements. Modularity and Tapers in total Joint Replacement Devices. STP1591, pp428-439. Greenwald AS, Kurtz SM, Lemons JE, Mihalko WM (Eds). ASTM International, West Conshohocken, PA, 2015.

  6. Kung M, Markantonis J, Nelson SD, & Campbell P. (2015).  The synovial lining and synovial fluid properties after joint arthroplasty. Special Issue: Tribological Performance of Artificial Joints.  Lubrication. 3(2), 394-412.

  7. Tan, T. L., Ebramzadeh, E., Campbell, P. A., Al-Hamad, M., & Amstutz, H. C. (2014). Long-term outcome of a metal-on-polyethylene cementless hip resurfacing. The Journal of Arthroplasty, 29(4), 802-807.

  8. Takamura, K. M., Amstutz, H. C., Lu, Z., Campbell, P. A., & Ebramzadeh, E. (2014). Wear analysis of 39 conserve plus metal-on-metal hip resurfacing retrievals. The Journal of Arthroplasty, 29(2), 410-415.

  9. K. De Smet, P. Campbell, C. Van Der Straeten: The Hip resurfacing Handbook. Woodhead Publishing, U.K., May 2013

  10. Van Der Straeten, C., Grammatopoulos, G., Gill, H. S., Calistri, A., Campbell, P. & De Smet, K. A. (2012)  “The 2012 Otto Aufranc award: The interpretation of metal ion levels in unilateral and bilateral hip resurfacing.” Clinical Orthopaedics and Related Research, 471(2): 377-85.

  11. Ebramzadeh, E., Campbell, P. A., Takamura, K. M., Lu, Z., Sangiorgio, S. N., Kalma, J. J., ... & Amstutz, H. C. (2011). Failure modes of 433 metal-on-metal hip implants: how, why, and wear. Orthopedic Clinics, 42(2), 241-250.

  12. Takamura, K. M., Yoon, J., Ebramzadeh, E., Campbell, P. A., & Amstutz, H. C. (2011). Incidence and significance of femoral neck narrowing in the first 500 Conserve® Plus series of hip resurfacing cases: a clinical and histologic study. Orthopedic Clinics, 42(2), 181-193.

  13. De Smet, K., De Haan, R., Calistri, A., Campbell, P. A., Ebramzadeh, E., Pattyn, C., & Gill, H. S. (2008). Metal ion measurement as a diagnostic tool to identify problems with metal-on-metal hip resurfacing. Journal of Bone and Joint Surgery, 90, 202-208.

PubMed Publications

http://www.ncbi.nlm.nih.gov/myncbi/browse/collection/49101155/?sort=date&direction=ascending